A microwave enhanced cross-metathesis approach to peptidomimetics.
نویسندگان
چکیده
Functionalization of amino acid C- and N-termini with appropriate olefinic moieties allows for the generation of a peptidomimetic via a stereoselective cross-metathesis.
منابع مشابه
The energetics of weakly polar interactions in model tripeptides.
Library Generation Analysis and Combinatorial Chemistry: dedicated to Bruce Merrifield 1 Bruce Merrifield Dynamic Combinatorial Assembly of Peptide-Rhenium Coordinates: Application to the Selection of hCyp-18 inhibitors from a Library of 12 × 16 Components 3 Dynamic Combinatorial Assembly of Peptide-Rhenium Coordinates: Coordination Chemistry for Generating New Analogs of hCyp-18 Ligands 5 Oxor...
متن کاملUnravelling the olefin cross metathesis on solid support. Factors affecting the reaction outcome.
Olefin cross metathesis on solid support under a variety of conditions is described. A comprehensive analysis considering diverse factors governing the reaction outcome gives a series of patterns for the application of this useful methodology in organic synthesis. If the intrasite reaction is not possible, homodimerization of the soluble olefin is crucial. When the homodimer is less reactive th...
متن کاملMicrowave-Assisted Syntheses of Bioactive Seven-Membered, Macro-Sized Heterocycles and Their Fused Derivatives.
This review describes the recent advances in the microwave-assisted synthesis of 7-membered and larger heterocyclic compounds. Several types of reaction for the cyclization step are discussed: Ring Closing Metathesis (RCM), Heck and Sonogashira reactions, Suzuki-Miyaura cross-coupling, dipolar cycloadditions, multi-component reactions (Ugi, Passerini), etc. Green syntheses and solvent-free proc...
متن کاملIsocyanide-based multicomponent reactions towards cyclic constrained peptidomimetics
In the recent past, the design and synthesis of peptide mimics (peptidomimetics) has received much attention. This because they have shown in many cases enhanced pharmacological properties over their natural peptide analogues. In particular, the incorporation of cyclic constructs into peptides is of high interest as they reduce the flexibility of the peptide enhancing often affinity for a certa...
متن کاملThe non-metathetic role of Grubbs' carbene complexes: from hydrogen-free reduction of α,β-unsaturated alkenes to solid-supported sequential cross-metathesis/reduction.
An efficient and high-yielding "hydrogen-free" reduction of α,β-unsaturated alkenes was carried out employing Grubbs' catalyst in a non-metathetic role and Et(3)SiH. Conditions were optimized under microwave irradiation. Application to the solid-phase organic synthesis allows a facile construction of sp(3)-sp(3) carbon bonds through a sequential cross metathesis/olefin reduction.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Organic & biomolecular chemistry
دوره 5 7 شماره
صفحات -
تاریخ انتشار 2007